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Self-reported adverse events after 2 doses of COVID-19 vaccine in Korea
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Yunhyung Kwon, Insob Hwang, Mijeong Ko, Hyungjun Kim, Seontae Kim, Soon-Young Seo, Enhi Cho, Yeon-Kyeng Lee
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Epidemiol Health. 2023;45:e2023006. Published online December 26, 2022
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DOI: https://doi.org/10.4178/epih.e2023006
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 Abstract
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Abstract
OBJECTIVES
In Korea, a national coronavirus disease 2019 (COVID-19) vaccination program was implemented, including 4 vaccines against COVID-19. A text messaging-based survey, in addition to a passive adverse event reporting system, was launched to quickly report unusual symptoms post-vaccination. This study compared the frequency of adverse events after COVID-19 vaccination based on the vaccine type and the type of 2-dose regimen (homologous or heterologous).
METHODS Self-reported adverse events were collected through a text-message survey for 7 days after each vaccination. This study included 50,950 vaccine recipients who responded to the survey at least once. Informed consent to receive surveys via text was obtained from the vaccine recipients on the date of first vaccination.
RESULTS The recipients of mRNA vaccines reported local and systemic reactions 1.6 times to 2.8 times more frequently after dose 2 than after dose 1 (p<0.001), whereas ChAdOx1-S recipients reported significantly fewer local and systemic reactions after dose 2 than after dose 1 (p<0.001). Local and systemic reactions were approximately 2 times and 4 times more frequent for heterologous vaccination than for BNT162b2/BNT162b2 and ChAdOx1-S/ChAdOx1-S regimens, respectively. Young individuals, female, and those receiving heterologous vaccine regimens including ChAdOx1-S/BNT162b2 vaccines reported more adverse events than older participants, male, and those with homologous vaccine regimens.
CONCLUSIONS Although a heterologous regimen, youth, and female sex were associated with a higher risk of adverse reactions after COVID-19 vaccination, no critical issues were noted. Active consideration of heterologous schedules based on the evidence of efficacy and safety appears desirable.
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Summary
Korean summary
본 연구는 코로나19 백신 접종 후 7일 동안 문자 설문조사를 통해 50,950명이 자가 보고한 이상반응자료를 분석하였다. mRNA 백신 접종자는1회 접종 후보다 2회 접종 후 국소 이상반응 및 전신이상반응을 1.6~2.8배 더 자주 보고한 반면, ChAdOx1-S 백신 접종자는1회 접종 후 보다 2회 접종 후 이상반응을 더 적게 보고하였다. 동종 백신접종 보다 교차 접종의 경우 2-4배 더 많은 이상반응을 보고 하였다. COVID-19 백신 접종 후 교차접종, 젊은 연령, 여성의 경우 좀 더 많은 이상반응을 보고하였지만,중대한 문제는 보고되지 않았다.
Key Message
Self-reported adverse events were collected through a text-message survey from 50,950 recipients for 7 days after COVID-19 vaccination. The mRNA vaccine recipients reported local and systemic reactions 1.6 to 2.8 times more frequently after dose 2 than after dose 1, whereas ChAdOx1-S recipients reported significantly fewer local and systemic reactions after dose 2 than after dose 1. Local and systemic reactions were approximately 2 to 4 times more frequent for heterologous vaccination than for homologous regimens. Although a heterologous regimen, youth, and female were associated with a higher risk of adverse reac¬tions after COVID-19 vaccination, no critical issues were noted.
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Citations
Citations to this article as recorded by  - Safety of a second homologous Ad26.COV2.S vaccine among healthcare workers in the phase 3b implementation Sisonke study in South Africa
Azwidihwi Takalani, Michelle Robinson, Phumeza Jonas, Annie Bodenstein, Vuyelo Sambo, Barry Jacobson, Vernon Louw, Jessica Opie, Jonny Peter, Pradeep Rowji, Ishen Seocharan, Tarylee Reddy, Nonhlanhla Yende-Zuma, Kentse Khutho, Ian Sanne, Linda-Gail Bekker
Vaccine.2024; 42(6): 1195. CrossRef - A Nationwide Survey of mRNA COVID-19 Vaccinee’s Experiences on Adverse Events and Its Associated Factors
Dongwon Yoon, Ha-Lim Jeon, Yunha Noh, Young June Choe, Seung-Ah Choe, Jaehun Jung, Ju-Young Shin
Journal of Korean Medical Science.2023;[Epub] CrossRef
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Main results of the Korea National Hospital Discharge In-depth Injury Survey, 2004-2016
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Sung Ok Hong, Boae Kim, Joongho Jo, Yunhyung Kwon, Yeon-Kyeng Lee, Youngtaek Kim
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Epidemiol Health. 2020;42:e2020044. Published online June 20, 2020
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DOI: https://doi.org/10.4178/epih.e2020044
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10,994
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Abstract
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Abstract
OBJECTIVES
The purpose of this study was to estimate the incidence of injuries and to identify their causes by classifying injuries according to various categories including age, sex, mechanism of injury, body parts injured, and place of injury.
METHODS This study used data from the Korea National Hospital Discharge In-depth Injury Survey (KNHDIS) from 2004 to 2016. The KNHDIS is conducted annually by the Korea Centers for Disease Control and Prevention, and its survey population includes all hospitalized patients discharged from medical institutions that have 100 or more beds, such as hospitals, general hospitals, and secondary community health centers. The number of injured cases is weighted and estimated using the mid-year estimated population of each year.
RESULTS The injury discharge rate steadily increased since 2004 (1,505 per 100,000 population in 2004, 2,007 per 100,000 population in 2016) and most injuries were unintentional (annual average of 94.7%). On average, during the 13-year study period, the injury rate for males was 1.5 times as high as for females. The 2 main causes of injury were consistently traffic accidents and falls. Notably, the rate of injuries resulting from falls rose by 1.7-fold from 463 to 792 per 100,000 people, and exceeded the rate of traffic accidents in 2016.
CONCLUSIONS The incidence of injuries steadily increased after the survey was first conducted, whereas mortality resulting from injuries mostly remained unchanged. This suggests that effective strategies and interventions should be reinforced to reduce unintentional injuries.
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Summary
Korean summary
질병관리본부가 2005년부터 구축하여 운영 중에 있는 퇴원손상심층조사의 연도별 조사자료를 분석한 결과 10만명당 손상발생규모는 2004년 1,505명에서 2016년 2,007명으로 지속적으로 증가하였다. 이러한 꾸준한 증가 추세는, 손상으로 인한 사망률은 감소하였을지라도 손상 예방을 위한 효과적인 정책과 전략, 지속적인 모니터링이 필요성을 제시한다.
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Citations
Citations to this article as recorded by - The Impact of the Association between Cancer and Diabetes Mellitus on Mortality
Sung-Soo Kim, Hun-Sung Kim
Journal of Personalized Medicine.2022; 12(7): 1099. CrossRef - Comparison of Prediction Models for Mortality Related to Injuries from Road Traffic Accidents after Correcting for Undersampling
Yookyung Boo, Youngjin Choi
International Journal of Environmental Research and Public Health.2021; 18(11): 5604. CrossRef
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Survival Rate and Factors Affecting Survival among Patients of Lung Cancer Lived in Daejeon City.
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Kil Hoi Lee, Yunhyung Kwon, Tae Yong Lee
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Korean J Epidemiol. 2003;25(2):62-75.
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Abstract
PURPOSE
This study was carried out to investigate survival rate and the factors affecting survival among lung cancer patients who have been registered in Daejeon Cancer Registry from 1998 to 2000.METHODS Kaplan-Meier method and Cox proportional hazard model were used to evaluate the factors affecting survival of lung cancer patients.RESULTS Lung cancer was more common in men than women, with an overall sex ratio in Daejeon, Korea of roughly 3:1. The incidence of lung cancer was 17.1 per 100,000 population in 1998, 21.4 in 1999, and 22.4 in 2000. Average age of incidence was 64.8 years old and 11.7% of study subjects having family history of lung cancer. Forty eight % of lung cancer was diagnosed as Stage III and 40.6% as Stage IV.
Histologically, squamous cell carcinoma was 39.7% of all and most frequent, and then adenocarcinoma 25.5%, and small cell carcinoma 19.3%. 3-year survival rate of female was higher than that of males, and that of smoker was the lowest among groups according to the smoking level. Survival rate by age fell dramatically in group over 70 years. Lung cancer patients diagnosed as Stage III and Stage IV had a much lower survival rate than those diagnosed as Stage I or II.
Stage, LDH and age were proved to be important variables that affect the mortality of lung cancer patients.CONCLUSION We found that the stage at diagnosis was a critical factor that affected the survival of lung cancer patients from this study. So It is essential to develop early diagnosis of lung cancer and then it needs to evaluate the effectiveness of that.
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